PARACETAMOL 250 MG + MEFENAMIC ACID 100 MG

DESCRIPTION

Meflom Suspension (Mefenamic acid 250 mg + Paracetamol 100 mg ) is specially formulated for children to provide effective relief from pain and fever. It helps manage toothache, body pain, sprains, strains and musculoskeletal discomfort in kids. The suspension works by reducing pain signals sent to the brain and also helps control fever by blocking substances responsible for pain and fever.

INDICATION

Fever – Meflom Suspension (Mefenamic acid 250 mg + Paracetamol 100 mg ) Helps effectively reduce elevated body temperature and provides quick comfort to children suffering from fever and associated weakness.

• Toothache – Meflom Suspension (Mefenamic acid 250 mg + Paracetamol 100 mg) Provides fast and soothing relief from dental pain, gum discomfort and irritation caused by tooth-related problems.

• Body Pain –  (Mefenamic acid 250 mg + Paracetamol 100 mg) Helps relieve general body aches, tiredness and discomfort, allowing children to feel active and comfortable.

• Muscle Pain – (Mefenamic acid 250 mg + Paracetamol 100 mg) Reduces muscle soreness, stiffness and pain caused by physical activity, strain or minor injuries.

• Sprains & Strains – (Mefenamic acid 250 mg + Paracetamol 100 mg) Helps ease pain, tenderness and discomfort associated with minor sprains, strains and soft tissue injuries.

• Musculoskeletal Pain – (Mefenamic acid 250 mg + Paracetamol 100 mg) Provides effective relief from pain affecting muscles, joints and bones, improving overall comfort and mobility.

• Headache – (Mefenamic acid 250 mg + Paracetamol 100 mg) Helps relieve mild to moderate headache and provides soothing comfort during fever or illness.

• Earache – (Mefenamic acid 250 mg + Paracetamol 100 mg) Helps reduce ear pain, irritation and discomfort commonly associated with infections or cold-related conditions.

• Cold & Flu Associated Pain – (Mefenamic acid 250 mg + Paracetamol 100 mg) Provides relief from fever, headache, body ache and discomfort associated with common cold and flu symptoms.

MECHANISM OF ACTION

Paracetamol (250 mg) : is a central acting analgesic and antipyretic with minimal anti-inflammatory effects. Its exact mechanism is not fully understood, but it is believed to inhibit COX-2 enzymes in the central nervous system, reducing prostaglandin synthesis. This helps alleviate pain and reduce fever. Paracetamol may also modulate the endocannabinoid system and interact with serotonergic pathways, enhancing its pain-relieving effects. It is effective for mild to moderate pain and fever, but its limited anti-inflammatory action makes it less suitable for conditions with significant inflammation.

Mefenamic acid (100 mg) : is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits both COX-1 and COX-2 enzymes, reducing the production of prostaglandins. This helps alleviate pain, inflammation, and fever, making it effective for conditions like musculoskeletal pain and dysmenorrhea. Its anti-inflammatory action also reduces swelling and redness. Additionally, it provides analgesic and antipyretic effects by blocking prostaglandins in the hypothalamus, regulating body temperature.

SIDE EFFECTS OF MEFLOM SUSPENSION

Major & minor side effects for Meflom Suspension 

• Nausea or Vomiting
• Allergic skin reaction
• Constipation
 

DRUG INTERACTIONS

Drug-Drug Interactions : Meflom Suspension (Mefenamic acid and Paracetamol) may interact with pain killers (aspirin, ibuprofen, celecoxib, diclofenac, naproxen), anti-gout (probenecid), immunosuppressants (cyclosporine, tacrolimus), anticoagulants (warfarin, heparin), anti-rheumatoid (methotrexate), anti-HIV (zidovudine), anti-depressant (duloxetine, lithium, fluoxetine, sertraline), steroid medication (mifepristone), anti-emetic (metoclopramide, domperidone), anti-cancer (imatinib), and bile acid sequestrants (cholestyramine).

Drug-Food Interactions : Avoid alcohol consumption while taking Meflom Suspension (Mefenamic acid and Paracetamol) as it might cause increased dizziness and risk of stomach bleeding.

Drug-Disease Interactions : Inform your doctor if you have peptic ulcers, bleeding disorders, asthma, fluid retention, gastrointestinal toxicity, rash, renal toxicity, thrombosis, anaemia, heart failure, liver toxicity, high blood pressure, platelet aggregation inhibition, or hyperkalemia (high potassium levels).

PRECAUTIONS

When using Meflom Suspension (Paracetamol 250 mg + Mefenamic Acid 100 mg) together, caution is necessary in patients with liver or kidney problems, as both drugs can affect these organs. Paracetamol should be used carefully in individuals with liver disease, and Mefenamic Acid, being an NSAID, may cause gastrointestinal issues, including ulcers and bleeding, especially in those with a history of GI disorders. Both drugs can interact with anticoagulants, increasing the risk of bleeding. Elderly patients and those with cardiovascular or renal conditions should be closely monitored. Mefenamic acid is contraindicated in the third trimester of pregnancy and should be used cautiously in early pregnancy. Overuse or exceeding recommended doses of either drug can lead to serious complications like liver damage or kidney failure.

DISCLAIMER
 

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.